Canadian Association of Pathologists
Association canadienne des pathologistes

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Case of the month 5

Clinical Summary
A 57 year old man presented with a one week history of shortness of breath and weakness. Two days before he had seen a physician and had been prescribed an oral antibiotic for "bronchitis". On examination in the ER, he was jaundiced and in pulmonary distress with a normal chest X-ray. He was admitted to ICU and died 10 hours after admission. An autopsy was performed.

Click on the thumbnails for a larger view of the image

This case was contributed
Dr. Denis Macdonald, University of Toronto
Dr. Martin Bullock, Dalhousie University

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MB-Image1.jpg (133333 bytes)

 
Low power of liver showing hepatic vein occluded by tumor
emboli within a portal tract with hepatic metastases (x25)
MB-Image2.jpg (92268 bytes)  
Low power of lung showing tumor microemboli (cytokeratin
immunostain)
(x25)

MB-Image3.jpg (85951 bytes)

 
High power of liver showing signet-ring cells in
microembolus (x100)
MB-Image4.jpg (105383 bytes)  
High power of lung showing signet-ring cells in vessels
(cytokeratin
7 immunostain)
 (x 100)
 

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